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0 · Role of microglial extracellular vesicles in the propagation of early
1 · Role of extracellular vesicles in early synaptic dysfunction in AD
2 · PRADA, Ilaria
3 · Microglial large extracellular vesicles propagate early synaptic
4 · Ilaria Prada
5 · Ilaria PRADA
6 · Glia
7 · Binding and Fusion of Extracellular Vesicles to the Plasma
8 · A new approach to follow a single extracellular vesicle
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Ilaria PRADA, PostDoc Position | Cited by 11,455 | of Italian National Research Council, Rome (CNR) | Read 48 publications | Contact Ilaria PRADA In the early stages of Alzheimer’s disease, Aβ starts to accumulate in specific areas of the brain, where it is internalized by microglia (1) and re-secreted in toxic form in association .
Prada I, Amin L, Furlan R, Legname G, Verderio C, Cojoc D. A new approach to follow a single extracellular vesicle-cell interaction using optical tweezers. Biotechniques. 2016;60:35–41. doi: .CNR Institutional Research Information System. IRIS; Pagina ricercatore; PRADA, Ilaria Nome completo. PRADA, Ilaria Tutti (10) Tutti (10) Contributo in rivista (10) Esportazione RIS; . Ilaria Prada 1 , Ladan Amin 2 , Roberto Furlan 3 , Giuseppe Legname 2 , Claudia Verderio 1 4 , Dan Cojoc 5 Affiliations 1 CNR Institute of Neuroscience, Milan, Italy.Morphological analysis reveals that prolonged exposure to inflammatory EVs leads to significant decrease in dendritic spine density in hippocampal neurons in vivo and in primary culture, .
Ilaria Prada, Martina Gabrielli, Giulia D'Arrigo, Ottavio Arancio, Claudia Verderio. First published: 07 December 2020. https://doi.org/10.1002/alz.045416. PDF. Tools. Share. .
Abstract. Exosomes and ectosomes, extracellular vesicles of two types generated by all cells at multivesicular bodies and the plasma membrane, respectively, play critical roles .Loop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, .
Ilaria Prada. CNR-Institute of Neuroscience, Vedano al Lambro (MB), Italy. Search for more papers by this author
Ilaria Prada Maria Passafaro Trehalose is a non-reducing disaccharide that has recently attracted much attention because of its ability to inhibit protein aggregation, induce autophagy, and .
Ilaria Prada [email protected] CNR-Institute of Neuroscience, Milan, Italy. Correspondence. Ilaria Prada, CNR-Institute of Neuroscience, Milan, Italy. Email: [email protected] Search for more papers by this author Background Synaptic dysfunction is an early mechanism in Alzheimer’s Disease (AD) which involves progressively larger areas of the brain over time. However, how it starts and propagates is unknown. .
We have uncovered a novel role for astrocytes-derived extracellular vesicles (EVs) in controlling intraneuronal Ca2+ concentration ([Ca2+]i) and identified transglutaminase-2 (TG2) as a surface-cargo of astrocytes-derived EVs. Incubation of hippocampal neurons with primed astrocyte-derived EVs have led to an increase in [Ca2+]i, unlike EVs from TG2-knockout . Funding. This work was supported by: the Austrian Multiple Sclerosis Research Society and Medical University of Graz (SA), the Italian Ministry of Research and University (PRIN project 2020Z73J5A to EV and grant GR 2016-02363254 to GD'A), the Alzheimer's Association Research Fellowship (AARF, grant 2018-AARF8 588984) (IP), the Synapsis Foundation - .
Introduction. Microglia are essential components of the innate immune response in the brain. They are self-renewing, long-lived cells, and stem from a unique non-haematopoietic yolk-sac-derived cell lineage (Ginhoux et al., 2010).They are multitasking cells involved in various functions under physiological and pathological states, participating in synaptic refinement, .Ilaria Prada. 1 CNR Institute of Neuroscience, via Vanvitelli 32, 20129 Milan, Italy . Find articles by Ilaria Prada. 1, Martina Gabrielli. . 8 CNR-Institute of Materials, Area Science Park, 34149 Trieste, Basovizza Italy . Find articles by Dan Cojoc. 8, Annalisa Buffo. Annalisa Buffo.
Introduction. Endocannabinoids (eCBs) are lipid messengers which potently modulate synaptic function 1.Their impact on synaptic transmission is widespread and diverse: Short-term forms of plasticity induced by eCBs have been described in numerous brain areas, while eCB-mediated modulation of long-term plasticity has implicated these bioactive lipids in . Martina Gabrielli, Natalia Battista, Loredana Riganti, Ilaria Prada, Flavia Antonucci, Laura Cantone, Marta Lombardi, Michela Matteoli, Mauro Maccarrone, and Claudia Verderio Martina Gabrielli Department of Medical Biotechnology and Translational Medicine, University of Milano, Milano, Italy Ilaria Prada [email protected] CNR-Institute of Neuroscience, Milan, Italy. Correspondence. Ilaria Prada, CNR-Institute of Neuroscience, Milan, Italy. Email: [email protected] Search for more papers by this author
Ilaria Prada CNR Institute of Neuroscience, Vedano al Lambro, MB 20854, Italy. Search for other works by this author on: Oxford Academic. PubMed. Google Scholar. . Nicola Origlia CNR Institute of Neuroscience, via Moruzzi 1 Pisa, 56124, Italy E-mail: [email protected]. Search for other works by this author on: Oxford Academic.
Ilaria Prada, CNR-Institute of Neuroscience, Vedano al Lambro (MB), Italy. Email: [email protected]. Abstract. Background: Synaptic dysfunction is an early mechanism in Alzheimer’s Disease (AD) Ilaria Prada, 1 Martina Gabrielli, 1 Elena Turola, 2 Alessia Iorio, 1 Giulia D’Arrigo, 3 Roberta Parolisi, 4 Mariacristina De Luca, 5 Marco Pacifici, 5 Mattia Bastoni, 6 Marta Lombardi, 7 Giuseppe Legname, 3 . Gabrielli M, Prada I, Giussani P, Viani P, Valtorta F, Menna E, Matteoli M, Verderio C. Sphingosine-1-Phosphate (S1P) impacts .
Ilaria Prada 3, Flavia Antonucci 1, Laura Cantone 1, Marta Lombardi 1, Michela Matteoli 1, . CNR-IN Neuroscience Institute, Department of Medicine, Milan, Italy. Ilaria Prada. European Center for Brain Research/IRCCS Santa Lucia Foundation, Rome, Italy. Natalia Battista. Authors.Ilaria PRADA, PostDoc Position | Cited by 11,455 | of Italian National Research Council, Rome (CNR) | Read 48 publications | Contact Ilaria PRADA
In the early stages of Alzheimer’s disease, Aβ starts to accumulate in specific areas of the brain, where it is internalized by microglia (1) and re-secreted in toxic form in association with EVs (2): the higher the Aβ cell load, the higher the Aβ content (as indicated by Bafilomycin experiments showed in this paper).Prada I, Amin L, Furlan R, Legname G, Verderio C, Cojoc D. A new approach to follow a single extracellular vesicle-cell interaction using optical tweezers. Biotechniques. 2016;60:35–41. doi: 10.2144/000114371.CNR Institutional Research Information System. IRIS; Pagina ricercatore; PRADA, Ilaria Nome completo. PRADA, Ilaria Tutti (10) Tutti (10) Contributo in rivista (10) Esportazione RIS; EndNote; BibTeX; Excel; CSV; RefWorks; Mostra records Risultati 1 - .
Ilaria Prada 1 , Ladan Amin 2 , Roberto Furlan 3 , Giuseppe Legname 2 , Claudia Verderio 1 4 , Dan Cojoc 5 Affiliations 1 CNR Institute of Neuroscience, Milan, Italy.Morphological analysis reveals that prolonged exposure to inflammatory EVs leads to significant decrease in dendritic spine density in hippocampal neurons in vivo and in primary culture, which is rescued in vitro by transfection of a miR-insensitive Nlg1 form. Ilaria Prada, Martina Gabrielli, Giulia D'Arrigo, Ottavio Arancio, Claudia Verderio. First published: 07 December 2020. https://doi.org/10.1002/alz.045416. PDF. Tools. Share. Abstract. Background. Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with amyloid-β (Aβ) and tau protein accumulation.
Abstract. Exosomes and ectosomes, extracellular vesicles of two types generated by all cells at multivesicular bodies and the plasma membrane, respectively, play critical roles in physiology and pathology.Loop is the open research network that increases the discoverability and impact of researchers and their work. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations.
Role of microglial extracellular vesicles in the propagation of early
Role of extracellular vesicles in early synaptic dysfunction in AD
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ilaria prada cnr|A new approach to follow a single extracellular vesicle
